Post-stroke cognitive impairment
Conditions
Interventions
Experimental group:Conventional treatment plus edaravone
Control group:Conventional treatment
Sponsors
First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
45 Years to 84 Years
Inclusion criteria
Inclusion criteria: 1. A diagnosis of ischemic stroke was made according to clinical criteria; 2. MRI or CT supports the diagnosis of acute cerebral infarction; 3. Aged >=45 years old male and female; 4. IQCODE=3, can complete neuropsychological testing; 6. Stroke within 2 weeks of onset; 7. The subjects are of primary school education or above and have the ability to complete the cognitive ability determination and other tests specified in the program; 8. Patient agreed and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Imaging evaluation without new cerebral infarction and asymptomatic lacunars infarction; 2. individuals who suffered from an uncorrectable visual or hearing dysfunction, or had difficulty completing the neuropsychological test; 3. Have been diagnosed with cognitive impairment and were using cholinesterase inhibitors or memantine; 4. individuals who suffered from psychosis, e.g., schizophrenia, bipolar affective disorder, severe depression, delirium; 5. Suffering from malignant tumors and heart, liver, kidney and other organ dysfunction or severe systemic diseases; 6. Missing laboratory indicators individuals: A-beta sLRP-1sRAGEFBGTGTCHDLLDLHcy; 7. Plasma A-beta, sLRP-1, sRAGE values were extreme values (The average value exceeds 3+/-SDs).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aß42;Aß40;sLRP-1;sRAGE; | — |
Countries
China
Contacts
Public ContactQu Qiumin
First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed