China Primary Health Care Foundation - Youan Foundation of Liver Disease and AIDS
Conditions
Interventions
1:Intravenous anesthesia with Propofol + Dexmedetomidine
2:Intravenous anesthesia with Propofol
Sponsors
Beijing You'an Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients scheduled for liver transplantation, aged 18 to 65 years, ASA grade II-III, and their family member signed informed consent.
Exclusion criteria
Exclusion criteria: Patients with hepatic encephalopathy (including period of prodromal and pre-coma) before surgery; those with liver failure;those with neuropsychiatric diseases; those taking psychotropic substances; patients with preoperative mini mental state examination (MMSE) scale score <24 points; those with vision or hearing impairment and patients having difficulty communicating and accomplishing the test; those with a history of drug abuse; patients with slow arrhythmia such as atrioventricular block (above II),sick sinus syndrome (including implantation of a pacemaker); patients with contraindications to magnetic resonance scans such as implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function;resting state functional magnetic resonance imaging;S-100ß??;neuron-specific enolase; | — |
Countries
China
Contacts
Public ContactChi Ping
Department of Anesthesiology, Beijing You'an Hospital, Capital Medical University
Outcome results
None listed