Major Depressive Disorder
Conditions
Interventions
vortioxetine:vortioxetine
escitalopram:escitalopram
Sponsors
The First Affiliated Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. This episode met the diagnostic criteria of DSM-V major depression; 2. First or recurrence without medication; 3. Hamilton depression rating scale HAMD-17 total score >= 17; 4. Han Chinese, right-handed; 5. Junior high school education or above; 6. Aged 18 to 45 years.
Exclusion criteria
Exclusion criteria: 1. Received antidepressant or other psychiatric medication, or other antidepressant treatment such as transcranial magnetic stimulation and electroconvulsive therapy; 2. Comorbidity or having been diagnosed with other mental disorders, or a first-degree relative with a history of mental disorders; 3. Secondary mental disorders caused by drugs or organic factors; 4. Have a history of major neurological diseases (such as epilepsy, stroke, etc.), major physical diseases (such as heart disease, hypertension, liver disease, etc.), and endocrine diseases (such as diabetes, etc.); 5. A history of alcohol or drug abuse or dependence; 6. MRI contraindication (e.g. metal implants, claustrophobia, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Psychological assessment scale;fMRI; | — |
Countries
China
Contacts
Public ContactManli Huang
The First Affiliated Hospital, College of Medicine, Zhejiang University
Outcome results
None listed