Acute cardiogenic pulmonary edema with hypercapnia of different PaCO2 levels
Conditions
Interventions
Experimental group:Double level positive airway pressure ventilation
Control group:Continuous positive airway pressure ventilation
Sponsors
The Second Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) the patient met the diagnostic criteria for acute cardiogenic pulmonary edema (according to the history, typical symptoms and signs), and the results of blood gas analysis suggested PaCO2> 40mmhg; (2) the subjects have clear consciousness, can cooperate with the treatment, and obtain the informed consent of the patients;
Exclusion criteria
Exclusion criteria: (1) contraindistions of non-invasive positive pressure ventilation: cardiac arrest, weak spontaneous breathing, coma, etc., requiring immediate endotracheal intubation, high possibility of aspiration, facial trauma/postoperative/deformity, patient's non-cooperation, etc.; (2) hemodynamic instability caused by severe heart failure, acute respiratory failure caused by non-cardiac factors, and acute cardiogenic pulmonary edema occurred in pregnant women, infants and children.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endotracheal intubation rate;Mortality in 30 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| PaCO2 in arterial blood gas analysis;PH in arterial blood gas analysis;NT-proBNP in plasma;Troponin in plasma; | — |
Countries
China
Contacts
Public ContactWang Xiaolong
The Second Affiliated Hospital of Chongqing Medical University
Outcome results
None listed