Genetic Polymorphism
Conditions
Interventions
Sponsors
Department of Anesthesiology of Xijing Hospital
Eligibility
Sex/Gender
Male
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) From March 2019, patients who are scheduled to undergo general anesthesia and radical laryngeal cancer resection in the Department of Otolaryngology Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, aged 40-70 years; ASA II-III grade; 2) The informed consent has been signed; 3) Patients received sufentanil intravenous analgesia after operation.
Exclusion criteria
Exclusion criteria: 1) Liver and kidney dysfunction (such as ALT > 40U/L, STB > micromol/L, etc.); 2) Combination of nephrotoxic drugs (amphotericin B, aminoglycoside antibiotics, etc.); 3) Take CYP3A enzyme inducers or inhibitors (such as rifampicin, macrolides, etc.) within 2 weeks before administration; 4) Complications such as acute infection; 5) Take other drugs that can cause abnormal liver function, such as chloramphenicol, chlorpromazine, etc.; 6) Patients with other diseases that can cause abnormal liver function, such as viral hepatitis, alcoholic liver disease, autoimmune hepatitis, respiratory tract diseases causing hypoxia, bacteremia, etc.; 7) Smoking, alcoholism, diabetes, severe cardiovascular disease, chronic kidney disease, chronic pain history, long-term use of analgesics, etc.; 8) Failure to comply with or unwilling to cooperate, and unclear understanding of the language used in the study; 9) Have participated in this study or other clinical studies at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sufentanil consumption; | — |
Countries
China
Contacts
Public ContactZeng Yi
Xijing Hospital, the Fourth Military Medical University
Outcome results
None listed