bronchiectasis
Conditions
Interventions
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged older than 18 years; 2. Confirmed diagnosis of bronchiectasis by HRCT within 12 months; 3. Able to expectoration spontaneously at baseline; 4. Clinically stable and has no exacerbations for at least four months prior to recruitment; 5. no antibiotic therapy for at least four months.
Exclusion criteria
Exclusion criteria: 1. Traction bronchiectasis; 2. Lesions of small area of pulmonary segments at HRCT; 3. Diagnosis of other pulmonary diseases such as asthma, COPD, pneumonia and so on; 4. Respiratory symptoms (including cough, sputum production, recurrent exacerbations) not predominantly the result of bronchiectasis in the opinion of the PI; 5. Diagnosis of digestive system diseases, hyperpiesia, hyperglycaemia or hyperlipemia; 6. Any history of cancers, severe heart disease(such as malignant arrhythmia, acute MI) or participants receiving LTOT; 7. Any history of serious active disease affecting survival outcomes within 12 months such as lung transplantation; 8. Serious, uncontrolled disease (including serious psychological disorders) likely to interfere with the study or impact on subject safety; 9. Prescription of either oral or intravenous antibiotic therapy in the preceding 4 weeks; 10. Have evidence of alcohol or drug abuse; 11. Unable to complete the required procedures for any reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| genomics;transcriptomics;transcriptomics;protomics;lipidomics;microbiome;immunohistochemical analysis;glycomics;virus;fungi;SEN, SPE, ACC, AUC of ROC; | — |
Countries
China
Contacts
Public ContactFuqiang Wen
West China Hospital, Sichuan University
Outcome results
None listed