Dynamic study for the effects of chemotherapy and bone marrow transplantation on ovarian function in preadolescent hematological disease survivors

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1900024799

Enrollment

Unknown

Registered

2019-07-28

Start date

2019-07-25

Completion date

Unknown

Last updated

2019-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Children with haematological diseases

Interventions

1:Chemotherapy

2: Bone marrow transplantation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Tanner stage pre-puberty children (evaluated by gynecologists, Tanner stage is no more than stage III). 2. Patients who meet the diagnostic criteria for blood diseases (including leukemia, aplastic anemia, myelodysplastic syndrome, multiple myeloma, lymphoma, etc.); Bone marrow transplant patients include: aplastic anemia, leukemia, lymphoma, myelodysplastic syndrome, thalassemia, etc.); 3.Sign the informed consent voluntarily.

Exclusion criteria

Exclusion criteria: 1. Menstruation; 2. Abnormal sexual development (including congenital ovary dysplasia, namely Turner syndrome, XO/XY gonadal dysplasia, simple gonadal dysplasia, true hermaphroditism, congenital adrenocortical hyperplasia, androgen insensitivity syndrome); 3. Those who have received radiotherapy; 4. Tumors affecting gonadal function.

Design outcomes

Primary

Measure	Time frame
FSH;	—

Countries

China

Contacts

Public ContactYang Xin

People's Hospital of Peking University

xinyang_2003@sina.com+86 13701318932

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026