NLRP3 inflammasome and perioperative neurocognitive dysfunction

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1900024750

Enrollment

Unknown

Registered

2019-07-26

Start date

2019-08-01

Completion date

Unknown

Last updated

2019-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative neurocognitive dysfunction

Interventions

POCD versus non POCD:Arthroscopic surgery

Eligibility

Sex/Gender

All

Age

65 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. More than 65 to 90 year old; 2. ASA grade II-III; 3. Spinal anesthesia is adopted; 4. The surgical procedure was hip or knee replacement.

Exclusion criteria

Exclusion criteria: 1. Contraindication of spinal anesthesia; 2. Preoperative history of cognitive dysfunction (stroke, neurological disease or mental illness); 3. Anemia patients with poor preoperative general condition, severe liver and kidney function impairment or Hb < 90g/l; 4. Long-term use of drugs that affect cognitive function, alcohol or drug abuse; 5. Patients with MMSE<=23 and who cannot complete blood sample collection or cognitive function assessment; 6. Patients who are unable to communicate normally (including those with limited hearing, dysgraphia, language barrier and deaf-mute); 7. Patients with massive intraoperative blood loss (over 800ml/l) or intraoperative blood transfusion.

Design outcomes

Primary

Measure	Time frame
NLRP3 inflammasome;a7nAChR;IL-1 beta;Patient cognitive function;IL-18;caspase1;	—

Secondary

Measure	Time frame
IL-6;TNF-a;	—

Countries

China

Contacts

Public ContactJanjun Li

Qilu hospital of shandong university (Qingdao)

ljj9573@163.com+86 18561811399

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026