Chronic hepatitis B
Conditions
Interventions
1:IFN and NUC
2:NUC
Sponsors
Beijing You'an Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 72 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: The criteria for diagnosis of HBeAg-negative CHB in China's Guidelines for the Prevention and Treatment of Chronic Hepatitis B (2015 edition) were in line with the following points: (1) aged 18-60 years, gender-unlimited; (2) treatment with pegylated interferon combined with sequential nucleotide analogues for at least 96 weeks.
Exclusion criteria
Exclusion criteria: (1) patients with HAV, HCV, HDV, HEV infection and autoimmune liver disease; (2) pregnant women, lactating women and patients who are about to give birth in the near future; (3) severe liver dysfunction or decompensated cirrhosis; (4) a history of severe heart disease, including unstable or uncontrolled heart disease within 6 months; (5) a history istory of mental illness or mental illness. (6) there is uncontrollable epilepsy. (7) unabstained alcoholics or drug addicts. (8) uncontrolled diabetes mellitus, hypertension, thyroid diseases, retinopathy, autoimmune diseases, etc. (9) neutrophil count < 110 *10 ^9/L and/or platelet count < 50 *10 ^9/L before treatment. (10) total bilirubin 51 umol/L (especially indirect bilirubin).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immunological changes; | — |
Countries
China
Contacts
Public ContactRen Shan
Beijing You,an Hospital, Capital Medical University
Outcome results
None listed