Lung injury
Conditions
Interventions
Group A:PEEP=0 cmH2O
Group B:PEEP=5 cmH2O
Group C:PEEP=8 cmH2O
Group D:PEEP=10 cmH2O
Sponsors
Jiangsu Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. 120 patients who are in accordance with ASA (American Association of Anesthesia Physicians) Grade II and III level are going to have left thoracotomy and esophageal cancer radical resection; 2. The patients signed the written informed consent; 3. Male or Female aged from 18 to 79 years.
Exclusion criteria
Exclusion criteria: 1. Patients with coronary heart disease, cerebral infarction history, liver and kidney insufficiency, severe respiratory dysfunction; 2. Patients with preoperative chemotherapy history, systemic infection; 3. Patients with blood products imported during the operation; 4. Patients with body mass index >=30kg/m2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulse oxygen saturation, SpO2;Oxygenation index and Intrapulmonary shunt value (QS/QT);Airway Ppeak, Pplat, Cldyn;Oxygen saturation of cerebral and kidney;Serum TNF-a, IL-6, IL-10, MDA, SOD;Number of cases of postoperative pulmonary infection and hospitalization days;PaO2, SaO2;PH, PaCO2;VD/VT; | — |
Countries
China
Contacts
Public ContactLianbing Gu
Jiangsu Cancer Hospital
Outcome results
None listed