Spinal cord stimulation to treat spastic paraplegia after spinal cord injury

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1900024719

Enrollment

Unknown

Registered

2019-07-23

Start date

2019-07-29

Completion date

Unknown

Last updated

2019-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

spinal cord injury

Interventions

1:spinal cord stimulation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 22-65 years; 2. Spastic paraplegia caused by traumatic spinal cord injury or after spinal surgery; 3. ASIA A, B, C or D Spinal Cord Injury Classification; 4. Brain and spinal cord MRI to exclude cerebral palsy, multiple system atrophy, adrenoleukodystrophy, multiple sclerosis, primary lateral sclerosis, tumor, cerebrovascular disease, traumatic brain injury and central nervous structural abnormalities; 5. Spinal cord injury between C6 and T10; 6. Spinal cord injury for more than one year, no improvement after at least 6 months conservative treatment; 7. No use of botulinum toxin within 6 months; 8. Willing to undergo regular follow-up and related evaluation; 9. Competence to decide to enroll and sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Severe cardiopulmonary diseases or other serious diseases that are not suitable for surgery; 2. Unhealed fractures, severe muscle contracture, muscle pain, hemorrhoids or urinary tract infection that might interfere with postoperative rehabilitation; 3. Clinical significant psychiatric illnesses or substance abuse; 4. Dementia, Parkinson's disease or epilepsy; 5. Osteoporosis; 6. Pregnancy; 7. Mechanical ventilation; 8. Active implanted cardiac pacemaker or defibrillator; 9. Progressive worsening of spastic paraplegia after spinal cord injury; 10. Coma; 11. Pregnancy.

Design outcomes

Primary

Measure	Time frame
spasticity;Electrophysiology;Walking Index for Spinal Cord Injury (WISCI II);10-Meter Walk Test (10MWT);	—

Secondary

Measure	Time frame
Health Status Questionnaire (SF-36);Berg balance scale;Change in blood pre;Gait analysis;Neurogenic bowel dysfunction score;Neurogenic bladder symptom score;Visual Analogue Scal;sex function questionnaire;	—

Countries

China

Contacts

Public ContactLiu Song

Capital Medical University

dr_songliu2018@163.com+86 13501343651

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026