The effect of different dose of atropine infused with dexmedtomidine on the incidence of bradycardia in spinal anesthesia

The impact of infusing different dose of atropine combined with dexmedtomidine on the incidence of bradycardia in spinal anesthesia

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900024715

Enrollment

Unknown

Registered

2019-07-23

Start date

2019-08-01

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

varicocele

Interventions

C group:infusing dexmedetomidine without atropine in it

A1 group:infusing dexmiedetomidine with 12.5ug/ml in it

A2 group:infusing dexmiedetomidine with atropine 25ug/ml in it

A3 group:infusing dexmiedetomidine with atropine 50ug/ml in it

Eligibility

Sex/Gender

Male

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Undergoing elective high ligation of spermatic veins, require for sedation during surgery, ASA status I or II, aged >= 18 yrs.

Exclusion criteria

Exclusion criteria: Patients who were not indicated for spinal anesthesia, had previous history of anticholinergic use before entering the operating room, and had hypersensitivity to dexmedetomidine administration. Also, patients were excluded if they failed spinal anesthesia or had a level higher than T6. Inability to consent to the study, coagulopathy, allergy to LA, prior surgery in the lumbosacral spine.

Design outcomes

Primary

Measure	Time frame
incidence of bradycarida;	—

Secondary

Measure	Time frame
Blood pressure;Heart rate;incidence of tachycardia;Ramsay sedation score;demogaraphic date;	—

Countries

China

Contacts

Public ContactLin Wenqian

The First Affiliated Hospital of Fujian Medical University

fymzk@outlook.com+86 18965086552

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026