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Effect of low tidal volume combined with positive end-breath pressure on respiratory function in infants undergoing laparoscopic surgery: a randomized controlled clinical trial

Effect of low tidal volume combined with positive end-breath pressure on respiratory function in infants undergoing laparoscopic surgery: a randomized controlled clinical trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900024697
Enrollment
Unknown
Registered
2019-07-22
Start date
2019-08-01
Completion date
Unknown
Last updated
2019-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung protection ventilation strategy

Interventions

1:The tidal volume is 6 ± 8 ml ·kg ~ (- 1), peep is the low inflection point of pressure-capacity ring (2 cm H2O), I :E = 1: 1.5, the respiratory rate is 35 ±60 mm H2O, FIO2 is 45%.
2:The tidal volume was 10-12 ml / kg, and the other respiratory parameters without PEEP, were the same as those in group 1.

Sponsors

Zhujiang Hospital, Southern Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 3 Years

Inclusion criteria

Inclusion criteria: Type of operation: abdominal laparoscopic surgery (poor intestinal torsion, choledochal cyst, duodenal atresia, annular pancreas, hypertrophic pylorus stenosis, intestinal atresia, intestinal stricture, megacolon, cryptorchidymis), 1 month < 3 years old infants, operation time 1 to 5 hours, their guardians signed informed consent for the study.

Exclusion criteria

Exclusion criteria: 1 ASA grade > IV; 2 perinatal asphyxia and resuscitation; 3 risk of shock and pulmonary hemorrhage; 4 meconium aspiration syndrome; 5 ARDS; 6 pneumothorax; 7 participation in other clinical studies.

Design outcomes

Primary

MeasureTime frame
Postoperative pulmonary complications;

Countries

China

Contacts

Public ContactZhang Qingguo

Zhujiang Hospital, Southern Medical University

zjyyzqg@126.com+86 13580586538

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026