hepatocellular carcinoma
Conditions
Interventions
HS group:synchronous hepatectomy and splenectomy
H group:hepatectomy alone
Sponsors
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years, male or female; 2. Clinical diagnosis of hepatocellular carcinoma with posthepatitic cirrhosis hypersplenism: (1) imaging confirmed splenomegaly; (2) 50x10^9/ L< PLT < 100x10^9/ L); 3. Child-pugh liver function was classified as grade A, or grade B but recovered to grade A after treatment; 4. Hepatocellular carcinoma, BCLC stage A; 5. No other antitumor therapy or immunotherapy were performed before surgery; 6. No serious organic diseases of the heart, lungs, brain or other organs; 7. No history of other malignancies; 8. Patient's survival is expected to exceed 3 months; 9. Voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating women; 2. A history of organ transplantation; 3. If there is any history of esophageal and gastric varicose vein rupture and bleeding or if there is "red sign" in this gastroscopy; 4. Active bleeding caused by various causes; 5. Suffering from serious acute or chronic diseases; 6. Severe diabetes; 7. Having a serious infectious disease; 8. HIV infection or AIDS related diseases; 9. Substance abuse, or mental or other disorders that may interfere with research compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DFS at 3 years after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| OS at 3 years after surgery;Postoperative liver function;Postoperative immune function;Postoperative quality of life;Incidence of postoperative complications;Postoperative complication severity;Postoperative morbidity;Postoperative mortality; | — |
Countries
China
Contacts
Public ContactZhang Zhiwei
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed