Acute aplastic anemia
Conditions
Interventions
Group 1:HLA-haplo HSCT
Group 2:HLA-matched sibling HSCT
Sponsors
Second Affiliated Hospital of Army Medical University, PLA
Eligibility
Sex/Gender
All
Age
3 Years to 25 Years
Inclusion criteria
Inclusion criteria: It conforms to the diagnostic criteria of acute aplastic anemia in the European Guidelines for the Diagnosis and Treatment of Aplastic Anemia 2010, and meets the following criteria for admission: (1) Less than 25 years old; KPS score > 60, estimated survival > 3 months; (2) No serious systemic damage to vital organ function; (3) The time from diagnosis to transplantation was not more than 3 months and no ATG treatment was received; (4) HLA matched sibling donor or HLA haploidentical donor; (5) Voluntary subjects, informed consent.
Exclusion criteria
Exclusion criteria: (1) Hereditary hematopoietic failure disease; (2) Patients who cannot follow up on schedule; (3) Patients who are unable to complete the necessary treatment plan and follow-up observation are not guaranteed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| over survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Event-free survival;Graft versus Host Disease;Infection; | — |
Countries
China
Contacts
Public ContactLei Gao
Second Affiliated Hospital of Army Medical University, PLA
Outcome results
None listed