maysthenia gravis
Conditions
Interventions
FK506 group:routine+FK506 therapy
RTX group:routine+RTX therapy
Thymectomy group:routine+Thymectomy therapy
FK506+Thymectomy group:routine+FK506+Thymectomy therapy
RTX+Thymectomy group:routine+RTX+Thymectomy therapy
Sponsors
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Confirmed diagnosis of myasthenia gravis, that is, according to the consensus of experts in myasthenia gravis in China, the typical myasthenia symptoms of fluctuating fatigue, pharmacological tests or electrophysiological tests positive; 2. Onset aged <=14 years old; 3. AChR-Ab or Musk-Ab positive; 4. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with heart disease, abnormal liver and kidney function, abnormal blood system, chronic infection or tumor (excluding thymoma); 2. Patients who persisted in withdrawing from the group due to non-adverse drug reactions (e.g. those who were unable to pay for the drug or were switching to Chinese medicine alone).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MGFA rating scale;Immunological marks;Thymus tissue;Thymus(CT/MRI scan); | — |
Secondary
| Measure | Time frame |
|---|---|
| Gene;Drug concentration;Thyroid function; | — |
Countries
China
Contacts
Public ContactBitao Bu
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed