morbid obesity
Conditions
Interventions
Obesity and diabetes group I:Use propofol to perform anesthesia
Obesity and diabetes group II:Use sevoflurane to perform anesthesia
Obesity without diabetes group I:Use propofol to perform anesthesia
Obesity without diabetes group II:Use sevoflurane to perform anesthesia
Sponsors
Department of Anesthesiology, the First Affiliated Hospital, Jinan University, Guangzhou
Eligibility
Sex/Gender
All
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: (1) According to the New York Heart Association Classification (NYHA), the assessment of cardiac function is II-III,BMI >40kg/m2; (2) Diagnosed as a diabetic according to the guidelines for the prevention and treatment of type 2 diabetes in China (3) Estimate the operation time between 2-2.5H; (4) According to the American Society of anesthesiologists standard ASA grade level II-III; (5) The function of lung, liver and kidney is normal, no other diseases such as cardiovascular system; (6) Patient is not allergic to propofol. (7) Aged 20 to 35 years.
Exclusion criteria
Exclusion criteria: (1) Patients with severe cardiovascular disease, history of stroke and renal vascular disease, renal failure, severe liver disease, and pheochromocytoma. (2) With history of smoking; (3) Neurological dysfunction, patients taking psychotropic drugs recently; (4) In addition to simple obesity, people with hypertension.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hypoxia inducible factor-1;Inflammatory mediator;Blood glucose metabolism index;Blood concentration; | — |
Countries
China
Contacts
Public ContactXuemei Peng
The First Affiliated Hospital, Jinan University
Outcome results
None listed