Diminished ovarian reserve(DOR)
Conditions
Interventions
Treatment group:Acupuncture
Control group:Acupuncture at non-acupoint
Sponsors
Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Patients less than 40 years old, will do IVF-ET; 2. Low ovarian reserve: AFC < 7, or AMH < 1.1ng/ml; or has a history of poor ovarian response: in the last hyper stimulation cycle, the number of retrieved oocytes < 3; 3. Spouse semen examination is normal, or after semen prewash can reach the standard of common IVF or Intracytoplasmic Sperm Injection (ICSI).
Exclusion criteria
Exclusion criteria: 1. Male with azoospermia; 2. Male/females chromosome is abnormal; 3. Adenomyosis, uterine fibroids, endometrial polyps, scar uterine, reproductive system tuberculosis, oviduct effusion, pelvic lesions such as ovarian endometriosis cyst or tumor; 4. Female has other endocrine disease: thyroid diseases, hyperprolactinemia, insulin resistance, diabetes, adrenal diseases, etc. 5. Definitively diagnosed autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome; 6. Other pathogenesis that leads to recurrent miscarriage or agnogenic recurrent miscarriage; 7. A history of cancer and has received radiotherapy and chemotherapy; 8. Had acupuncture treatment in recent 3 months; 9. Unwilling to sign the informed consent of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum AMH;serum inhibin;serum FSH;serum LH;AFC;Gn dosage;Gn usage days;E2 level on HCG day;Endometrial thickness on HCG day;number of oocytes;MII oocytes;normal fertility rate;the number of available embryos;number of high-quality embryos;cycle cancellation rate (including cycle cancellation rate caused by various reasons);implantation rate: including fresh periodic implantation rate, per cycle implantation rate and cumulative implantation rate;fresh cycle clinical pregnancy rate and cycle cumulative clinical pregnancy rate;early, mid and late pregnancy abortion rate;risk of ovarian hypertrophy and incidence of obstetric complications;FSH, LH, E2 and AMH in follicular fluid;Oxidative stress related indicators in follicular fluid such as ROS, SOD level, etc.;live rate: including fresh cycle live rate, cycle live rate and cumulative live rate.;neuro-endorphin (neuro-et);dopamine (DA);beta-aminobutyric acid (GABA);5-hydroxytryptamine (5-ht);adrenaline;norepinephrine;blood corticotropin-releasing hormone (CRH);acupuncture gas scale (MASS);Zung anxiety self-rating scale (Zung-SAS);Zung depression self-rating scale (Zung-SDS);SF-36;Chinese quality of life scale (CHQOL); | — |
Countries
China
Contacts
Public ContactHanwang Zhang, Dongmei Huang
Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology
Outcome results
None listed