Anti-Inflammatory and Analgesia Effect of Local Periarticular Infiltration Injection Combined Ketorolac With betamethasone in Total Knee Arthroplasty: A prospective Randomized Controlled Trial

Anti-Inflammatory and Analgesia Effect of Local Periarticular Infiltration Injection Combined Ketorolac With betamethasone in Total Knee Arthroplasty: A Prospective Randomized Controlled Trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900024571

Enrollment

Unknown

Registered

2019-07-17

Start date

2019-07-18

Completion date

Unknown

Last updated

2019-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total knee arthroplasty

Interventions

A:Single Ropivacaine peri-anticular infiltarion

B:Ropivacaine and ketorolac peri-anticular infiltarion

C:Ropivacaine,ketorolac and betamethasone peri-anticular infiltarion

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Aged 18 to 85 years; Undertake total knee arthroplasty; Informed consent is available.

Exclusion criteria

Exclusion criteria: (1)History of drug allergy; (2)Severe hepatic and renal dysfunction; (3)Opioids consumption for chronic disease.

Design outcomes

Primary

Measure	Time frame
Function scales outcomes;Rest Pain;Activity pain;CRP;IL-6;Range of motion;	—

Secondary

Measure	Time frame
Complication;	—

Countries

China

Contacts

Public ContactZongke Zhou

West China Hospital, Sichuan University

zhouzongke@scu.edu.cn+86 13904412120

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026