Acquired immunodeficicency syndrome and acute respiratory failure
Conditions
Interventions
ARDS-net group:PEEPsettded by ARDS-net
PTP group:PEEP guided by the PTP
Sponsors
Beijing Ditan Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Obtaining informed consent; 2) Aged >= 18 years; 3) In accordance with the diagnosised criteria for AIDS in China AIDS diagnosis and treatment plan (third edition); 4) Meeting the criteria of the diagnostic criteria of acute respiratory distress syndrome (Berlin standard) for moderate to severe ARDS, but the time from onset to respiratory failure can be more than one week; 5) Invasive mechanical ventilation was given in the ICU for less than 8 hours.
Exclusion criteria
Exclusion criteria: 1) past medical history with chronic pulmonary diseases (COPD, asthma, bronchiectasis); 2) cardiogenic pulmonary edema (diagnosised by echocardiography or PICCO monitoring); 3) hemodynamic instability (SBP is lower than 90mmHg and tissue perfusion is insufficient after volume expansion and pressure booster support, or SBP > 180mmHg); 4) active bleeding exists;Acute coronary syndrome within one week, or presence of severe arrhythmia; 5) severe intracranial hypertension or neuromuscular lesions; 6) pregnancy; 7) patients with esophageal and gastric fundus lesions or surgery; 8) contraindications to respiratory mechanics; 9) pneumothorax, subcutaneous emphysema and obvious pulmonary bullae were present.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PaO2/FiO2 ratio; | — |
Countries
China
Contacts
Public ContactAng Li
Beijing Ditan Hospital Affiliated to Capital Medical University
Outcome results
None listed