AIDS complicated with cryptococcal meningitis
Conditions
Interventions
Case group:none
Control group:Nil
Sponsors
Beijing Youan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: AIDS combined with CM patients into the group criteria: 1. AIDS patients in our hospital infection center combined with CM patients, gender and age are not limited; 2. AIDS and CM diagnostic criteria in line with the 2015 Ministry of Health of the People's Republic of China "AIDS treatment guidelines (The third edition) and the 2018 edition of the United States "Guidelines for the Prevention and Treatment of Opportunistic Infections for Adults and Adolescents with HIV Infection". All patients were positive for anti-HIV-1 antibodies by enzyme-linked immunosorbent assay (ELISA) screening and Western blotting (WB). The diagnostic criteria for CM: cerebrospinal fluid smear staining can be seen as positive for Cryptococcus neoformans or culture; 3. patients in the prospective cohort require initial HIV antibody positive and HAART has not been initiated; 4. can be combined with treatment and monitoring, signed informed consent Booker. HIV negative control population (n=20), age matched with AIDS and CM patients. HIV-negative controls were selected from hospitalized patients with neurosyphilis in our hospital infection center. The inclusion criteria required no central nervous system infection and could be checked and voluntarily signed informed consent.
Exclusion criteria
Exclusion criteria: Case group: (1) Patients who are unable to cooperate with treatment and monitoring and incomplete clinical data; (2) Those who refuse to sign informed consent. Control group: Those who were suspected or had a central nervous system infection, could not cooperate with the examination, and refused to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cytokine; | — |
Countries
China
Contacts
Public ContactLi Aixin
Beijing You'an Hospital, Capital Medical University
Outcome results
None listed