schizophrenia
Conditions
Sponsors
Shenzhen University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. At least 18 years of age; 2. ICD-10 diagnosis of schizophrenia, confirmed with the MINI interview; 3. Written Informed Consent; 4. Fully capable of making their own decision regarding participation in the study; 5. Stable pharmacological treatment at least two weeks prior to the start of the study; 6. Patients remain on their regular medication for the complete duration of the study; 7. Minimum score of 27 on the short version of the Apathy Evaluation Scale (AES-C).
Exclusion criteria
Exclusion criteria: 1. comorbidities of severe mood or neurological disorders, current alcohol or substance dependence disorder; 2. insufficient language abilities to perform tests in a valid way; 3. Metal implants in head/brain; 4. (suspected) pregnancy; 5. Diagnosis of epilepsy, or a personal or first degree family history of epileptic seizures; 6. Brain surgery; 7. Intracerebral implants; 8. Been treated with electroconvulsive therapy within six months; 9. severe cognitive deficit.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apathy Evaluation Scale, AES;Scale for Assessment of Negative Symptoms, SANS;Brief Negative Symptom Scale, BNSS;brain structural magnetic resonance imaging;brain resting-state functional magnetic resonance imaging;frontal cortex magnetic resonance spectroscopy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-International Neuropsychiatric Interview, MINI;Positive and Negative Syndrome Scale, PANSS;Clinical Global Impression scale, CGI;Schizophrenia Quality of Life Scale, SQLS;Snaith-Hamilton Pleasure Scale, SHAPS;Temporal Experience of Pleasure Scale, TEPS;Neuropsychological tests; | — |
Countries
China
Contacts
Public ContactPengfei Xu
Center for Brain Disorders and Cognitive Science, Shenzhen University
Outcome results
None listed