Essential tremor
Conditions
Interventions
Group 1 versus Group 2:PSA/VIM Deep brain stimulation
Sponsors
Department of Functional Neurosurgery, RuiJin Hospital, affiliated with Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years old at the time of enrollment; 2. Based on MDS 2017 consensus diagnosis for primary tremor; 3. Duration of ET symptoms: >=3 years of motor symptoms; 4. If the patient takes a tremor medication, the tremor drug is stable 28 days prior to informed consent; 5. Written informed consent was signed prior to entering the study.
Exclusion criteria
Exclusion criteria: 1. Mental illnesses that may affect the subject's ability to comply with the research protocol requirements (eg, biphasic, schizophrenia, mood disorders with psychotic characteristics, group B personality disorder); 2. Severe cognitive impairment, MOCA <24; 3. Any drug or alcohol abuse currently under the DSM-V standard; 4. Any intracranial abnormalities that impede DBS surgery; any history of recurrent or unprovoked seizures; any previous treatment for dyskinesia involves intracranial surgery or instrument implantation; any history of hemorrhagic stroke; there may be any interference with the study procedure or may confuse the study endpoint Major disease assessed; 5. Life expectancy for any lifetime, <1 year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TRS;frequency of EMG; | — |
Secondary
| Measure | Time frame |
|---|---|
| VDI;Base frequency perturbation;Amplitude perturbation;Irregularity;Overall severity;DSI;MSDA test;International Cooperative Ataxia Rating Scale;Walking speed;Step size;Time per step;Step width;Dual support time;Percentage of missed steps; | — |
Countries
China
Contacts
Public ContactDianyou Li
Department of Functional Neurosurgery, RuiJin Hospital, affiliated with Shanghai Jiaotong University School of Medicine
Outcome results
None listed