Pain palliation of the bone metastases
Conditions
Interventions
Experimental group:Focus Ultrasound Treatment
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged from 18~70 years; 2. Patients who has been diagnosed as bone metastases according to the medical history or MR examination; 3. The target metastases is back to the ribs, limbs, pelvis, shoulder joint and spine under the L3 vertebral (included); 4. Target lesion is clearly observed under the non-enhanced magnetic resonance imaging; 5. Irrespective of medication, patient with NRS (0-10 scale) pain score >=4, The source of pain can be distinguished, and targeted part of the treatment NRS pain score is at least 2 scores higher than the other pain parts; 6. Patient haven't received radiation therapy to the targeted(most painful) lesion in the past two weeks prior to the study; 7. Patients who are voluntary and have given written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who receive chemotherapy aimed at palliating or radiation therapy to targeted painful lesion in the past two weeks prior to the study; 2. Fracture risk score >7; 3. The skin on the beam pathway has damage or ulceration; 4. Disease which have an inclination of bleeding; 5. Patients with life expectancy 100 on medication); 9. Patients with standard contraindications for MR imaging such as non-MRI compatible implanted metallic devices or claustrophobia; 10. Patients who have mental disorder in the past or have recognition disable; 11. Pregnancy or Lactation; 12. Patients who are participating or have participated in another clinical trial in the past 30 days; 13. Patients who are in other circumstances which the researchers regards are not appropriate for clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The efficacy of HIFU treatment for pain palliation of bone metastases 90±7 days after the surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| the numerical rating scale circumstances before the surgery and 7±1days, 30±7days and 90±7days after the surgery Secondary Outcome Measures;he score of brief pain inventory-quality of life (BPI-QoL) before and 7±1 days, 30±7 days and 90±7 days after the surgery;the record of pain medications usage.; | — |
Countries
China
Contacts
Public ContactWang Han
Shanghai General Hospital
Outcome results
None listed