cervical cancer
Conditions
Interventions
Case series:rhG-CSF
Sponsors
Beijing Cancer Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years; 2. histologically confirmed squamous cell carcinoma of the cervix (2018 FIGO stage IIIC1, IIIC2, IVA); 3. According to the researcher's judgment, if rh-CSF is not accepted, the risk of FN is >20%. with Risk factors of FN; and chemotherapy regimen (paclitaxel/paclitaxel liposome + cisplatin) is planned; 4. KPS score >=70; 5. ANC>=2.0x10^9/L, HB>=80g/L, PLT>=90x10^9/L; 6. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Currently has uncontrolled infection, or has been treated with systemic antibiotics within 72 h prior to chemotherapy; 2. Bone marrow dysplasia and other hematopoietic abnormalities; 3. Previous bone marrow or hematopoietic stem cell transplantation within 3 months; 4. Previously had other malignant tumors that were not cured or had brain metastases; 5. Total bilirubin (TBIL), alanine aminotransferase (ALT) and AST are >2.5 times the upper limit of normal value in liver function examination; 6. Renal function examination: upper limit of 1.5 normal serum creatinine (Cr); 7. Allergic to this product or other biological products from genetically engineered escherichia coli; 8. Suffering from mental or neurological disorders and unable to cooperate; 9. Pregnant or lactating female patients; Women in pregnancy age refusing to accept contraception; 10. Unsuitable for inclusion by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of level III or IV neutropenia; | — |
Countries
China
Contacts
Public ContactXiaofan Li
Beijing Cancer Hospital
Outcome results
None listed