Cardiac Surgery
Conditions
Interventions
1:continuous use of inflammatory cytokine adsorbers during cardiopulmonary bypass to remove cytokines
2:without use of inflammatory cytokines adsorbers during cardiopulmonary bypass
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. adult patients (aged >18 years); 2. meeting one of the following conditions (1) with infective endocarditis; (2) combined with heart, or lung, or liver, and or kidney failure before cardiac surgery; (3) scheduled for total aortic arch replacement surgery under deep hypothermic circulatory arrest. 3. serum TNF-a>8.1 umol/L.
Exclusion criteria
Exclusion criteria: 1. patients involved in other intervention experiments; 2. pregnancy; 3. glucocorticoid consumption for long-term; 4. combined with immune system diseases, such as HIV-infection; 5. Informed consent not obtained.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| all-cause mortality during 30 days;new onset organ dysfunction;endotracheal intubation for more than 24 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| length of hospital stay;total hospitalization expenses; | — |
Countries
China
Contacts
Public ContactLei Du
Department of Anesthesiology, West China Hospital, Sichuan University
Outcome results
None listed