gynecological laparoscopic surgery
Conditions
Interventions
Group A:naborphine 0.75mg/ml + hydromorphone 25µg/ml
Group B:naborphine 0.67mg/ml + hydromorphone 33µg/ml
Group C:naborphine 0.5mg/ml + hydromorphone 50µg/ml
Group D:naborphine 0.33mg/ml + hydromorphone 67µg/ml
Group E:naborphine 0.25mg/ml + hydromorphone 75µg/ml
Sponsors
The First Affiliated Hospital of Inner Mongolia Medical University
Eligibility
Sex/Gender
Female
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1 ASA grade I or II; 2 Gynecological laparoscopic surgery patients; 3 Preoperative cognitive function was normal; 4 Aged 40-65 years; 5 Body mass index 19-29 kg/m2. 6 No history of drug abuse, chronic pain and mental illness.
Exclusion criteria
Exclusion criteria: 1 History of abdominal surgery; 2 Diffuse peritonitis; 3 Severe adhesion of giant uterus or pelvic cavity; 4 Second-degree and above atrioventricular block, bradycardia (HR < 50 beats / min) and hypotension (SBP < 90mmHg); 5 Low pulmonary function; 6 Complicated with coagulation dysfunction, severe brain, liver and kidney insufficiency, endocrine system diseases and severe infectious diseases; 7 Patients with serious mental and psychological diseases can not cooperate with treatment and patients with language disorder; 8 Suspected or confirmed history of alcohol and drug abuse; 9 Allergic to naborphine hydrochloride and hydromorphone hydrochloride or their components, or patients with a history of opioid allergy; 10 Patients with limited gastric emptying or gastroparesis; 11 Patients with intestinal peristalsis or intestinal obstruction; 12 Patients who had participated in clinical trials of other drugs within nearly 4 weeks; 13 Patients with other circumstances, the researchers believe that patients who are not suitable for selection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ramsay sedation score;The total consumption of PCIA;PCA effective times;Changes of blood pressure, heart rate, respiration and oxygen saturation;Satisfaction with analgesic effect;Incidence of adverse reactions;Length of hospital stay;The recovery time of postoperative gastrointestinal function;The urinary catheter residence time after operation; | — |
Countries
China
Contacts
Public ContactYu Jianshe
The First Affiliated Hospital of Inner Mongolia Medical University
Outcome results
None listed