Diabetic Kidney Disease
Conditions
Sponsors
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
25 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Accord to the western diagnostic criteria for type 2 diabetes, or previous history of diabetes; 2. Phase III DKD standard, the screening and early detection of urinary albumin/creatinine ratio (ACR) are accord with 30 ~ 300 mg/g; 3. Syndrome differentiation of TCM syndrome type is kidney Yang deficiency; 4. Normal serum creatine; 5. After basic treatment, blood glucose was controlled in HbA1c < 8.5%, FPG < 9mmol/L, 2h postprandial blood glucose < 13.0mmol/L, and blood pressure was controlled in < 140/90mmhg. 6. Male and female aged 25-70 years old; 7. Sign informed consent form.
Exclusion criteria
Exclusion criteria: 1. Type 1 diabetes; 2. Patients with severe primary cardiovascular and cerebrovascular diseases, liver and kidney dysfunction and hematopoietic system diseases; 3. Infection, severe electrolyte disorder and other aggravating factors which are not controlled or the patients whose conditions are unstable; 4. Excluding patients with a variety of primary and secondary renal diseases and diseases caused by hypertension, heart failure, acidosis and urinary tract infection with increased urinary protein; 5. Mentally ill; 6. Women who are pregnant or preparing for pregnancy or lactation; 7. Patients who need long-term hormone therapy; 8. Hypertension that is difficult to control, or secondary hypertension; 9. The patients who the investigator expects poor compliance or inability to cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TCM syndrone score;ACR; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting blood-glucose;HbA1c;Blood fat;eGFR;Urine targeted metabolomics;The number of urinary foot cells and the expressions of pcx-1, nephrin and CD2AP in urinary sediment; | — |
Countries
China
Contacts
Public ContactLu Fuer
Department of Integrated Traditional Chinese and Western Clinical Medicine, Tongji Hospital, Tongji Medical College, Hua Zhong University of Science and Technology
Outcome results
None listed