Hypertension
Conditions
Interventions
Sponsors
Guang'anmen Hospital, China Academy of Chinese Medical Science
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Male or female,between the age of 45-80years; (2) Office blood pressure :120SBP <= 140mmHg,DBP < 90mmHg (according to baseline screened measurement -office blood presure will be measured in a standardized fashion); (3) Stable dose of antihypertensive drugs for at least 3 months ; (4) Treated with moderate dose of two or more antihypertensive drugs for at least 12 months.According to the guidelines,antihypertensive drugs are defined as any ACE inhibitor,angiotensinII recepor blocker,calcium channel blocker,thiazide and thiazide-like diuretic,potassium-sparing diuretic,beta-blocker,vasodilator antihypertensives,centrally acting antihypertensives,direct renin inhibitors,adrenergic neuron blocking drugs or loop diuretics; (5) Eligible patients will be willing to particpate the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Secondary hypertension or previous diagnosed resistant hypertension; (2) Serious cardiovascular system,pulmonary system,liver,kidney system and nervous sysytem disease,psychiatric disorders,cancer,infectious diseases or others,limiting ability to participate in the Baduanjin or aerobic exercise programs and influencing reduction or discontinuation of antihypertensive drugs; (3) Using other drugs that may sffect blood presure; (4) Smoking and/or alcohol abuse; (5) Pregnancy or women who are planning to be pregnant; (6) Enrolled in other clinical trials in the last 3 months; (7) Practiced Baduanjin or other similar types of physical activities in the past 3 months,such as Qi Gong,yoga and Tai Chi; (8) Taken antibiotics,probiotics or yogurt within latst 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Withdrawal rate of antihypertensive drugs; | — |
Secondary
| Measure | Time frame |
|---|---|
| 24-hour ambulatory blood pressure mean change and blood pressure variability;Office blood pressure;Quantitative grading of symptoms of hypertension;Blood sugar and blood lipid levels;Quality of Life Scale (SF-36);Changes in gut microbial composition; | — |
Countries
China
Contacts
Public ContactWu Min
Guang'anmen Hospital, China Academy of Chinese Medical Science
Outcome results
None listed