The comparison of preemptive oral celecoxib and acetaminophen on postoperative pain scores and NSAID consumption after third molar surgery: a randomized controlled trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900024426

Enrollment

Unknown

Registered

2019-07-11

Start date

2019-08-01

Completion date

Unknown

Last updated

2020-07-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative pain of tooth extraction

Interventions

1:oral celecoxib 200mg 30 minutes before surgery

2:oral acetaminophen 500mg 30 minutes before surgery

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1. at least 18 years old; 2. X - ray showed mandibular impacted teeth; 3. consented to the trial.

Exclusion criteria

Exclusion criteria: 1. pregnancy or lactation; 2. with other serious diseases include liver, kidney and cardiovascular diseases; 3. hypersensitivity to COX-2 inhibitor; 4. Ulcers or bleeding in the digestive tract; 5. Unable to express subjective discomfort symptoms; 6. caries or periapical periodontitis, periodontal disease with adjacent teeth; 7. allergic history of steroidal drugs; 8. Took analgesic and anti-inflammatory drugs for one week.

Design outcomes

Primary

Measure	Time frame
the intensity of pain;time for the first analgesic rescue medication;total analgesic consumption during 24 hours;	—

Countries

China

Contacts

Public ContactXie Long

Hospital of Stomatology, Wuhan University

kq000905@whu.edu.cn+86 13972399564

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026