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The association of early fluid resuscitation and acute organ dysfunction: a case records based study

The association of early fluid resuscitation and acute organ dysfunction: A multicenter, retrospective cohort study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900024418
Enrollment
Unknown
Registered
2019-07-10
Start date
2019-07-09
Completion date
Unknown
Last updated
2019-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

septic shock

Interventions

Case series:Nil

Sponsors

The 8th Medical Center of Chinese PLA General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. To meet the diagnostic criteria for septic shock recommended by SSC 2016 guidelines(1.to meet the sepsis Sepsis 3.0 diagnostic criteria; 2. Despite adequate fluid resuscitation, hypotension persists; 3. To maintain MAP (> 65 mmHg) with vasoactive drugs; 4. Blood lactic acid (> 2 mmol/L) to stay in ICU for more than 72 hours.

Exclusion criteria

Exclusion criteria: 1. Age < 18 years old; 2. End-stage diseases such as malignant tumors or family members abandoning treatment; 3. Confirmed diagnosis of acute myocardial infarction or acute pulmonary infarction; 4. serious granulocytopenia and other hematological diseases in primary diseases; 5. chronic renal failure patients requiring regular dialysis; 6. patients undergoing large organ transplantation within 1 year; 7. surgical infections whose source of infection has not been effectively controlled; 8. Pregnancy (non-puerpera).

Design outcomes

Primary

MeasureTime frame
Blood lactic acid;Oxygenation index;serum creatinine;total bilirubin;platelet counts;Glasgow Coma Score;

Countries

China

Contacts

Public ContactJingtao Liu

The 8th Medical Center of Chinese PLA General Hospital

ljt309@sohu.com+86 13910697082

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026