type 2 diabetes
Conditions
Interventions
Group A:Use premixed insulin and metformin
Group B:Use premixed insulin and shaaglitine
Group C:Use short-acting insulin + long-acting insulin
Group D:Use short-acting insulin + long-acting insulin and shaaglitine
Sponsors
The First Affiliated Hospital of Bengbu Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (all 6 should be met) : 1 Type 2 diabetes was diagnosed according to WHO standards in 1999; 2 Premixed insulin treatment regimen (yusilin 30R/ ganshulin 40/60) failed to reach the standard (HbA1c failed to reach > for 3 months); 3 7.5% =19 and <=35 kg/m2; 6 Able to understand the procedures and methods of this study, willing to complete this study in strict accordance with the clinical trial protocol, and willing to sign the informed consent.
Exclusion criteria
Exclusion criteria: (excluded if one of them meets) : 1 Type 2 diabetic patients with tolerance to metformin; 2 Compliance with the study drug 2 times normal value or alanine aminotransferase > 2 times normal value and/or total bilirubin > 2 times normal value, and confirmed by reexamination within 3 days; Fasting triglyceride > 5.64mmol/L (500mg/dl); Serum creatinine exceeds the upper limit of the normal range; Thyroid stimulating hormone exceeds the upper limit of normal value and has clinical signi
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood glucose;glycosylated hemoglobin;blood fat;Islet C peptide;glucagon;Dipeptidyl peptidase -4;Glucagon - like peptide -1;T cell subset;Transforming growth factor-beta (TGF-ß);B-cell activating factor (BAFF);interleukin-10;Carotid intima-media thickness; | — |
Countries
China
Contacts
Public ContactJin Guoxi
Department of Endocrinology, the First Affiliated Hospital of Bengbu Medical College
Outcome results
None listed