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Propranolol disrupts smoking memory reconsolidation

Disrupting smoking-related memory reconsolidation attenuates craving and diminishes anterior cingulate cortex reactivity to smoking cues in smokers

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900024412
Enrollment
Unknown
Registered
2019-07-10
Start date
2017-04-01
Completion date
Unknown
Last updated
2019-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nicotine addiction

Interventions

control group:Placebo (Vitamin C)
experimental group :Propranolol

Sponsors

Peking University Sixth Hospital
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: The inclusion criteria for smokers were the following: (1) right-handed, (2) smoking eight or more cigarettes per day over the past year, and (3) Fagerstrom Nicotine Dependence Test (FDNT) score >= 4.Each participant provided written informed consent in the study.

Exclusion criteria

Exclusion criteria: Participants were excluded if they had cardiovascular diseases, had used addictive drugs other than nicotine, had a current or past history of Diagnostic and Statistical Manual of Mental Disorders, 4th edition, Axis I disorders, were currently using antidepressants or had clinically evident cognitive impairment, or took any prescription drugs during the 2 weeks prior to the experimental sessions. The participants were free from MRI contraindications.

Design outcomes

Primary

MeasureTime frame
Craving;—

Countries

China

Contacts

Public ContactLin Lu

Peking University Sixth Hospital

linlu@bjmu.edu.cn+86 10-82805308

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 21, 2026