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Efficacy and safety of simvastatin ointment for the treatment of xanomatosis or juvenile xanthogranuloma

Efficacy and safety of simvastatin ointment for the treatment of xanomatosis or juvenile xanthogranuloma

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900024410
Enrollment
Unknown
Registered
2019-07-10
Start date
2018-01-01
Completion date
Unknown
Last updated
2023-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

xanomatosis and juvenile xanthogranuloma

Interventions

Xanomatosis Group:For xanomatosis, three different concentrations of the experimental drugs were topical given twice daily
Juvenile xanthogranuloma:For juvenile xanthogranuloma, three different concentrations of the experimental drugs were topical given twice daily

Sponsors

Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 70 Years

Inclusion criteria

Inclusion criteria: 1. Clinical and pathological diagnosis: juvenile xanthogranuloma or xanthomatosis; 2. Stable vital signs; 3. Subjects or guardians agree to participate in this study and sign the informed consent; 4. Aged juvenile xanthogranuloma <12 years old; Xanthomatosis <70 years old; There is no limitation on the gender.

Exclusion criteria

Exclusion criteria: 1. Severe allergies or infections were found in the skin lesions of the disease in this study; 2. Allergic to the study medicine; 3. Patients who have been treated with oral lipid-lowering drugs in the past three months; 4. Have precancerous skin lesions; 5. Severe cardiac, hepatic and renal insufficiency; 6. Patients who are lactating, pregnant or have potential pregnancy during treatment and refuse to use contraception; 7. unable to adhere to treatment; 8. Enroll in any other clinical trial.

Design outcomes

Primary

MeasureTime frame
clinical menifestation;Pathological changes;

Countries

China

Contacts

Public ContactZhirong Yao

Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine

yaozhirong@xinhuamed.com.cn+86 13651652986

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026