sepsis
Conditions
Interventions
Presepsin monitoring treatment group:Adjust antibiotics according to presepsin test results
Routine treatment group:Adjust antibiotics according to clinical manifestations
Sponsors
Beijing Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 120 Years
Inclusion criteria
Inclusion criteria: 1. Severe sepsis patients admitted to ICU conform to the third international consensus definition of sepsis and septic shock (Sepsis-3) in 2016. Diagnostic criteria for sepsis is suspected or confirmed infections and a sharp increase in SOFA scores (organ dysfunction) above 2. 2. Aged older than 18 years, gender is not limited; 3. (1) Laboratory examination results of urine, cerebrospinal fluid, ascites, pleural effusion and secretions of infected lesions suggest infection. (2) Imaging findings of CT, X-ray, ultrasonography and MRI indicated infection, and excluded non-infectious causes. (3) Microbiological examination results of positive results of blood culture, sputum culture and other body fluid and secretion culture. Satisfy any one of the above provisions, with evidence of infection.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or lactation patients; 2. Patients with various advanced tumors; 3. Patients staying in ICU for less than 2 days; 4. Patients with antibiotic allergy or allergic constitution; 5. Long-term use of immunosuppressive agents; 6. Other situations in which the researcher considers it impossible to be included in the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of days without antibiotics in 28 days;presepsin; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day mortaility;Basic clinical data and laboratory test results; | — |
Countries
China
Contacts
Public ContactChunsheng Li
Beijing Friendship Hospital
Outcome results
None listed