Cardiac surgery under cardiopulmonary bypass
Conditions
Interventions
Control group:patients in the control group received an intravenous infusion of 2mL/kg of normal saline just 10 min before aortic cross-unclamping
Experimental group:patients in the experimental group received an intravenous infusion of 2mL/kg of 20% intralipid just 10 min before aortic cross-unclamping
Sponsors
Departement of Anesthesiology, West China Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult patients undergoing cardiopulmonary bypass in our hospital were eligible for participation if they met the following criteria: 1) there is written informed consent; 2) aged 18 to 70 years; 3) undergoing elective cardiac surgery under CPB; 4) ASA I - III level.
Exclusion criteria
Exclusion criteria: 1) LVEF < 30%; 2) redo cardiac surgery; 3) severe hepatic disfunction; 4) severe renal disease; 5) severe lung disease (or oxygenation index <120); 6) severe coagulation dysfunction; 7) severe hyperlipidemia; 8) any disorder associated with immunological disfunction (eg, malignancy or positive serological test for the HIV); 9) current infections; 10) aortic dissection; 11) preoperative treatment with nicorandil, sulfonylurea 12) preoperative treatment with intralipid in the last 1 month; 13) participating in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LVEF, LVEDS, LVEDD;CK-MB;BNP;cTNT;mortality rate;severe complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| mortality rate;survival quality;awake time;extubation time;length of stay in hospital;length of stay in intensive care unit;all-in cost of stay in hospital; | — |
Countries
China
Contacts
Public ContactRonghua Zhou
Departement of Anesthesiology, West China Hospital
Outcome results
None listed