Polycystic ovarian syndrome
Conditions
Interventions
A:liraglutide 0.6mg once daily and metformin 0.85g twice a day. And dinae-35 was prescribed that taking one pill per day for 21 days, and then stopping for 7days in every menstrual cycle.
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Meet the Rotterdam Criteria (2003): (1) oligoovulation and/or anovulation; (2) excess androgen activity; (3) polycystic ovaries (gynecologic ultrasound show the number of follicles which have diameters in 2-9mm in one or both ovaries more than 12). PCOS can be diagnosed if any 2 out of 3 criteria are met; 2. Aged between 18 ang 40 years; 3. BMI=24kg/m2
Exclusion criteria
Exclusion criteria: 1. Allergic to glucophage and liraglutide; 2. Type 1 or type 2 diabetes mellitus; 3. Significant cardiovascular, kidney, or liver disease; 4. Pregnant or breastfeeding; 5. Take any antidiabetic, antihypertensives, lipid-lowering drugs or hormone medicine recently; 6. Congenital adrenal cortical hyperplasia, Cushing's syndrome, Tumors that secretes androgen.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| weight; | — |
Secondary
| Measure | Time frame |
|---|---|
| BMI;Visceral fat area;PBF;Sex hormone;Blood lipid;oralglucose tolerance test,OGTT;insulin release test,IRT;HbA1C; | — |
Countries
China
Contacts
Public ContactYi Liu
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed