HBV-related hepatocellular carcinoma
Conditions
Interventions
ALPPS Group:liver partition+portal vein ligation
PVE Group:portal vein embolization
Sponsors
Eastern Hepatobiliary Surgery Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18 to 75 years; (2) An unresectable HBV-related HCC due to inadequate volume of FLR; (3) BCLC stage-0, A, and B; (4) Child-Pugh liver function Class A and baseline serum alanine aminotransferase (ALT) level<2 times the upper limit of normal; (5) Informed consent from the patient.
Exclusion criteria
Exclusion criteria: (1) resectable HCC; (2) unresectable HCC with intra- or extra-hepatic metastases; (3) severe portal hypertension defined as presence of liver stiffness>20kPa on FibroTouch assessment, and/or endoscopy showing esophageal varices not flattened by air insufflation; (4) an ASA operative risk>=3; (5) With history of anti-cancer therapy; (6) refusal to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| tumor resection rates;three-year overall survival rates; | — |
Secondary
| Measure | Time frame |
|---|---|
| the rates of increase in volume of FLR;the time to reach the predefined FLR volume for the stage-2 hepatectomy;intraoperative data;postoperative morbidity rates;postoperative mortality rates; | — |
Countries
China
Contacts
Public ContactWeIPing Zhou
Eastern Hepatobiliary Surgery Hospital
Outcome results
None listed