Meniere's Disease
Conditions
Interventions
expreimental group:prednisolone+MMF
control group:diuretics+methylprednisolone
Sponsors
Shandong Provincial ENT Hospital Affiliated to Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) All patients were diagnosed with definite unilateral or bilateral meniere's disease according to the diagnostic criteria of Meniere's disease formulated by Barany association in 2015. 2) The disease was in active phase, with fluctuating hearing and frequent vertigo attacks. In the latest three months, the average monthly vertigo attacks were more than 2. 3) Age and gender: gender is not limited; age is between 18 and 60 years old; liver and kidney function is normal.
Exclusion criteria
Exclusion criteria: 1) Aatients with cerebellar horn tumor or other intracranial space-occupying lesions shown in the internal auditory canal. 2) Exclude other vertigo diseases, such as posterior ischemia, vestibular migraine, BPPV, etc.. 3) Contraindications on the use of drugs. 4) May be confused with other diseases. 5) Pregnant and lactating women, and women considering pregnancy during the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| vergito attack controlling rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| hearing loss rate;speech recognition rate;change in tinnitus and ear fulness;life qulity assessment;vestibular function assessment;electrocochleogram;safety assessment; | — |
Countries
China
Contacts
Public ContactHaibo Wang
Shandong Provincial ENT Hospital Affiliated to Shandong University
Outcome results
None listed