xerostomia
Conditions
Interventions
Gold Standard:Saliva Flow Rate measurement as well as patient-reported xerostomia score questionare.
magnetic 
resonance 
imaging 
of 
and 
neck.
Sponsors
Department of Radiation Oncology, the First Medical Center affiliated General Hospital of Chinese PLA
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1 The primary tumors were HNSCC, primary sites including pharynx (including nasopharynx, oropharynx, hypopharynx), larynx and etc. 2 Tumors were locally advanced (according to AJCC 8 Head and Neck Tumor Staging Criteria: T1-4N2-3M0 but not T1-2N1M0 nasopharyngeal carcinoma, T3-4N0-1M0); 3 Good performance status: ECOG 0-1; 4 Age ranges from 18 to 70 years old. 5 Expected survival was more than 2 years. 6 Complete medical records (medical history, physical examination, related examinations, past treatment); 7 Feasible MR plain scan + enhanced examination, salivary flow rate measurement and periodic dry mouth assessment scale score; 8 Imaging examination (plain and enhanced MRI; color Doppler ultrasound of superficial cervical lymph nodes) to determine the extent of invasion and lymph node metastasis of primary lesions; 9 Neck and supraclavicular lymph node metastasis is allowed. 10 Voluntary participation and written informed consent.
Exclusion criteria
Exclusion criteria: 1 Because of liver and kidney dysfunction, severe hematological toxicity and medical complications, induction chemotherapy and concurrent chemotherapy cannot be performed. 2 Other diseases of rheumatic immune system such as Sjogren's syndrome in the past; 3 Salivary gland surgery or other physiotherapy; 4 Trauma history of head and neck surgery in the past; 5 History of head and neck radiotherapy; 6 Surgical intervention was performed; 7 There are metal implants such as dentures and prostheses in the mouth; 8 Claustrophobia; 9 Recurrence or distant metastasis within 2 years after radiotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| apparent diffusion coefficient;Ktrans;Mean kurtosis;saliva output flow rate; | — |
Countries
China
Contacts
Public ContactLin Ma
Department of Radiation Oncology, the First Medical Center affiliated General Hospital of Chinese PLA
Outcome results
None listed