Respiratory diseases of preterm infants
Conditions
Interventions
Sponsors
Guangxi Maternal and Child Health Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Preterm infants with Gestational age between 25+0 weeks to 33+6 weeks and birth weight <1500g; 2. Infants met the criteria of intubation, and requiring invasive MV of any mode on admission; 3. Only the first extubation from invasive ventilation was studied in this study.
Exclusion criteria
Exclusion criteria: 1. Infants with major life-threatening congenital malformations; 2. Infants died within 24h after admission; 3. Infants with abnormal upper airway structure (Pierre-Robin's syndrome, congenital laryngomalacia, choanal atresia, severe nose injury, etc.); 4. Infants with surgical diseases requiring surgery prior to extubation [congenital diaphragmatic hernia(CDH), congenital tracheal esophageal fistula(TEF), gastrointestinal malformations, and complex congenital heart disease (CHD), except for PDA ligation and surgical NEC); 5. Infants had stage IV intracranial hemorrhage (ICH) before extubation; 6. Infants with congenital lung diseases or lung dysplasia (such as congenital surfactant formation defects); 7. Infants who were transfer or discharge unexpectedly.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| oxygenation index;reintubation rate;duration of non-invasive ventilation;duration of O2 supplement;duration of PN;length of hospital stay; | — |
Secondary
| Measure | Time frame |
|---|---|
| pneumothorax;bronchopulmonary dysplasia;ventilation associated pneumonia;NEC (stage II and above);ROP (stage II and above);PDA;nasal injury;Girth while on Non-invasive Ventilation;IVH (grade 3 and above); | — |
Countries
China
Contacts
Public ContactYan Li
Guangxi Maternal and Child Health Hospital
Outcome results
None listed