Recurrent Implantation Failure
Conditions
Interventions
1:iodized oil intrauterine perfusion
2:none
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Aged 20 to 40 years females; 2. With spontaneous menstrual cycle; 3. Experienced three or more fresh or thaw ET cycles, at least 4 high-quality embryos at cleavage stage or 3 high-quality blastocysts were transferred and no clinical pregnancy was achieved. 4. There were still high-quality frozen embryos available for implantation. 5. Agreement and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Known factors that exactly affects embryo implantation, such as severe uterine adhesions, septum uterus, uterine leiomyoma, endometrial polyps, endometrial hyperplasia, uterine malignant tumors, hydrosalpinx, Adenomyosis and endometriosis, et al; 2. Anyone couples with chromosome abnormalities, which were considered interfering the development and implantation of embryos by genetic consultants; or male with seriously weak sperms; 3. Patients with hyperthyroidism or hypersensitivity to iodine; 4. Any women amenorrhea but not yet ruled out pregnancy; 5. Severe heart and lung disease; uncontrolled hypertension, diabetes and obesity (BMI >= 28); 6. The body temperature was higher than 37.5 degree C during the last 3 days before perfusion,; 7. Patients with serious pregnancy-related diseases such as luteal dysfunction, thyroid dysfunction, polycystic ovary syndrome, reproductive tract infection, uterine or cervical bleeding; 8. Any conditions that was unstable or unlikely to compliance of the pregnancy. 9. Any patients that was inappropriate to be treated with this regimen.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Pregnency;live birth; | — |
Secondary
| Measure | Time frame |
|---|---|
| Chemical pregnancy;Miscarriage; | — |
Countries
China
Contacts
Public ContactAiping Qin
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed