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Diagnostic ultrasound combined with microbubble in neoadjuvant chemotherapy for breast cancer: A clinical research on sensitization

Diagnostic ultrasound combined with microbubble in neoadjuvant chemotherapy for breast cancer: A clinical research on sensitization

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900024252
Enrollment
Unknown
Registered
2019-07-03
Start date
2018-01-01
Completion date
Unknown
Last updated
2019-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast cancer

Interventions

Control group:Without Ultrasonic treatment
Experimental group:diagnostic ultrasound combined with ultrasound microbubbles

Sponsors

Hubei Cancer Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) A patient confirmed to be breast cancer by histopathology; (2) female aged 18-75 years old; (3) Oncological assessment (ultrasound, CT or MRI) with measurable and evaluable individual tumor lesions; (4) The estimated survival time is more than 5 months; the PS score is 0-2 points; (5) Blood routine examination: WBC (white blood cells) >=3.5x10^9/L, ANC (neutrophils) >=1.5x10^9/L, PLT (platelets) = 80x10^9/L, Hb (hemoglobin) >=90g/L; (6) There is no obvious abnormality in liver and kidney function: ALT (alanine aminotransferase), AST (aspartate aminotransferase) <=2.5 times the upper limit of normal value, Urea (urea), Crea (creatinine) <=upper limit of normal value 1.25 times, the upper limit of ALT, AST <=normal value of patients with liver metastasis is 5 times; (7) Cardiopulmonary function is basically normal; (8) No history of other malignant tumors; (9) Good compliance and no mental disorders; (10) Sign the informed consent form.

Exclusion criteria

Exclusion criteria: (1) Does not meet the inclusion criteria; (2) Pregnancy or breastfeeding; (3) Allergic to chemotherapy drugs and hypersensitivity; (4) With massive ascites; (5) Associated with lung, brain and other pelvic organ metastasis; (6) Receiving other anti-tumor drugs or radiotherapy; (7) Participate in other clinical trials or chemotherapy at the same time for less than 4 weeks.

Design outcomes

Primary

MeasureTime frame
size of tumor;

Countries

China

Contacts

Public ContactZeng Shue

Hubei Cancer Hospital

739039061@qq.com+86 18986137799

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026