esophageal cancer
Conditions
Interventions
1:neoadjuvant radiotherapy
Sponsors
Wang Wei
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of thoracic esophageal cancer (cT1b-T4a,N-N+) as determined by clinical staging,required to undergo neoadjuvant radiotherapy and following resection according to the routine procedures. (1) Bulk of gastroesophageal junction tumor should be in the esophagus. (2) Bronchoscopy with biopsy and cytology required if primary esophageal cancer is 3 months; 3. WBC > 4,000/mm3; ANC > 1,500/mm3; Platelet count > 100,000/mm3; Hemoglobin > 9 g/dL; Bilirubin normal; Creatinine normal; AST <=3 times upper limit of normal (ULN); Alkaline phosphatase <= 3 times ULN. 4. Able to take oral medication or undergo enteral administration of medication; 5. Fertile patients must use effective contraception during and for 90 days after completion of study treatment; 6. No concurrent uncontrolled illness, including, but not limited to, any of the following: (1) Ongoing or active infection; (2) Symptomatic congestive heart failure; (3) Unstable angina pectoris; (4) Cardiac arrhythmia;; (5) Psychiatric illness or social situation that would preclude study compliance; 7. No known HIV or hepatitis B or C (active and/or previously treated).
Exclusion criteria
Exclusion criteria: 1. Pregnancy or lactation; 2. There are not enough specimens of tumor tissue or they can not be used for analysis and detection; 3. Refuse to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gene expression; | — |
Countries
China
Contacts
Public ContactWang Wei
Nanfang Hospital of Southern Medical University
Outcome results
None listed