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The mechanism of down-regulation of LSD1 gene in sepsis inducing hematopoietic stem cell expansion and promoting immune dysfunction

The mechanism of down-regulation of LSD1 gene in sepsis inducing hematopoietic stem cell expansion and promoting immune dysfunction

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900024226
Enrollment
Unknown
Registered
2019-07-01
Start date
2019-07-01
Completion date
Unknown
Last updated
2019-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

Sponsors

Dongzhimen Hospital of Beijing University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1 meet the diagnostic criteria of Sepsis 3.0; 2 aged 18 to 80 years; 3 sign the informed consent.

Exclusion criteria

Exclusion criteria: 1 the time of determination exceeds 48 hours; 2 pregnant or lactating women; 3 severe primary diseases that affect survival, including: uncontrolled malignant tumors that cannot be resected after metastasis, blood diseases and HIV; 4 continuous use of immunosuppressive agents or organ transplantation within the past 6 months; 5 continuous use of hormones 7 days before enrollment, which was converted into methylprednisolone dose >= 20mg/day; 6 participated in other clinical trials within 30 days; 7 the investigator judged that they could not complete the study or should not participate in the study (they were expected to die within 48 hours and refused active treatment).

Design outcomes

Primary

MeasureTime frame
Survival rate;

Secondary

MeasureTime frame
Bone marrow cell morphology;Blood cell morphology;Bone marrow cell Colony-Forming test;Cytokine release test;Transcription factor detection;Transcriptome analysis;Phenotype of bone marrow cell;Phenotype of blood cell;

Countries

China

Contacts

Public ContactWang Lan

5 Haiyuncang Lane, Dongcheng District, Beijing

wlxjok@163.com+86 13611383425

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026