Children disease
Conditions
Interventions
experimental group :Nalbuphine injection
control group:Morphine injection
Sponsors
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical Universtiy
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 1-7 years; 2. ASA I-II; 3. laparoscopic surgery; 4. Operation time less than 120 min; 5. Informed consent form signed by the parent or legal guardian.
Exclusion criteria
Exclusion criteria: 1. BMI>=28kg/m2 or = 28kg; 2. Be allergic to nalbuphine, its components and opioid medicine; 3 Preoperative using analgesic, sedatives, antiemetics or antipruritics in 24 h; 4. Preoperative body temperature was higher than 38 degree C or suffering from upper respiratory infection in 24h; 5. Suffered from bronchial asthma; 6. Suffering from severe obstructive sleep apnea syndrome and arrhythmia; 7. Having difficult airway. had abnormal surgery or anesthesia recovery. 8. BUN or CR > upper limitation of normal value; ALT or AST > upper limitation of normal value. 9. Suffered from severe traumatic brain injury in 6 month. intracranial hypertension. 10. Suffering from mental disease or cant express their mind exactly. 11. Sedatives or analgesics administration for a long time. 12. The blood loss >100 ml. 13. Participated another clinical trial of medicine in a month. 14. Score of FLACC cant accomplished with various reasons. 15. With other conditions, the investigator believe that it is not suitable for the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of children requiring rescue analgesia in PACU; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of children requiring rescue analgesia during operation;Heart rate and blood pressure;The removal time of laryngeal mask airway;Awaken time;FLACC pain score;Ramsay sedation score;Extra analgesia in PACU;Retention time in PACU;Anesthesia satisfaction score; | — |
Countries
China
Contacts
Public ContactHuacheng Liu
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical Universtiy
Outcome results
None listed