olfactory neuroblastoma
Conditions
Interventions
1:endoscopic surgery+radiotherapy
2:radiotherapy+/- endoscopic surgery
Sponsors
Eye, Ear, Nose, and Throat Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Sign of inform consent; 2. Age 18~70 years; 3. Pathological evidence of olfactory neuroblastoma; 4. Sensitive to chemotherapy: >=50% partial remission after chemotherapy; 5. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1; 6. Without metastasis; 7. General physical condition compatible with the proposed radiotherapy and surgery; Surgically resectable; 8. Acceptable organ function; 9. Patients with a prior history of squamous cell or basal carcinoma of the skin or in situ cervical cancer must have been curatively treated.
Exclusion criteria
Exclusion criteria: 1. Patients with evidence of distant metastases or leptomeningeal disease (LMD); 2. Patients received previous irradiation for head and neck tumor, skull base, or brain tumors; 3. Previous history of surgery or radiotherapy for current disease; 4. Patients with uncontrolled inter-current illnesses which in the opinion of the investigator will interfere with the ability to undergo therapy including chemotherapy; 5. Patients with a history of a different malignancy are excluded, unless the disease has not progressed for >= 2 years; 6. Contraindication for surgery; 7. Patients may have any co-existing condition that would preclude full compliance with the study; 8. Severe neuropathy or psychiatric disorders, including dementia and seizures; 9. Infectious disease out of control; 10. Women pregnant or breast-feeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall survival rate;Overall survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| life quality;Locoregional recurrence Free Suvival; | — |
Countries
China
Contacts
Public ContactXicai Sun
Eye, Ear, Nose, and Throat Hospital, Fudan University
Outcome results
None listed