Viral hepatitis
Conditions
Interventions
experimental group: integrated therapy combined with prophylactic antimicrobial therapy
control group: integrated therapy
Sponsors
Third Affiliated Hospital of Sun Yet-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years (including 18 and 65 years), men and women are not restricted; 2. HBsAg positive lasting at least 6 months; 3. Acute onset, ALT is more than 5 times the upper limit of normal value; 4. Serum total bilirubin (TB) reached 10-20 times the normal upper limit (10-20ULN); 5. The plasma prothrombin activity (PTA) was more than 40%; 6. Patients are capable and willing to provide informed consent and comply with the test requirements.
Exclusion criteria
Exclusion criteria: 1. Severe liver function damage can reach the diagnostic criteria for liver failure or decompensated cirrhosis; 2. Combined with any definite infection basis, or WBC > 10 x 10^9/L, the proportion of neutrophils is more than 75%; 3. Corticosteroids or antibiotics were used before hospitalization; 4. People with a history of severe basic diseases that is considered unsuitable for the study; 5. People with a history of allergy to a variety of antimicrobial agents; 6. Other causes of liver damage, such as autoimmune liver disease, drug-induced hepatitis, acute hepatitis E, alcoholic hepatitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of liver failure within 4 weeks;Decline rate of serum total bilirubin within 4 weeks; | — |
Secondary
| Measure | Time frame |
|---|---|
| The length of hospital stay;Procalcitonin; | — |
Countries
China
Contacts
Public ContactZiying Lei
The Third Affiliated Hospital of Sun Yet-Sen University
Outcome results
None listed