The role of gut flora and microbial metabolites in coronary heart disease patients with depressive symptoms

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900024163

Enrollment

Unknown

Registered

2019-06-28

Start date

2019-07-01

Completion date

Unknown

Last updated

2019-07-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary heart disease

Interventions

Bifidobacterium group:Bifidobacterium triple live capsule

Placebo group:Placebo capsule

Psychotherapy group:Psychotherapy

Control group:No

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: CHD meet the 1999 WHO criteria.

Exclusion criteria

Exclusion criteria: (1) history of depression or other psychiatric disorders (on anti-depressant medication, clinical diagnosis, or previous treatment); (2) acute infectious disease within the past month; (3) other severe cardiovascular diseases, such as acute pericarditis, myocarditis, end-stage heart failure, or secondary heart disease; (4) diseases seriously affecting life expectancy (such as connective tissue disease, tumors, drug abuse, and dementia); (5) pregnant women; and (6) recent major stressful life events, trauma, or surgery.

Design outcomes

Primary

Measure	Time frame
Psychological assessment;	—

Countries

China

Contacts

Public ContactLing Yang

Changzhou First People's Hospital (The Third Affiliated Hospital of Soochow University)

linda_yl@sina.com+86 13616110633

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026