renal and pulmonary function in elderly patients undergoing long-term general anesthesia and non-cardiac surgery
Conditions
Interventions
Dex group:input dexmedetomidine
Control group:input Saline
Sponsors
Anesthesiology Department of the First Affiliated Hospital of Army Medical University, PLA
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Aged 60-75 years old; (2) ASA grade I~III; (3) The estimated operation time is more than 4 hours; (4) The anesthesia method is general anesthesia; (5) The surgical procedure is open abdominal and thoracic surgery; (6) Ability to comply with research protocols, voluntarily participate in research and sign informed consent.
Exclusion criteria
Exclusion criteria: (1) ASA classification = IV; (2) patients with pheochromocytoma; (3) Those whose mental state cannot cooperate, who suffer from mental illness, have no self-control, and cannot express clearly; (4) Those who are participating in other clinical trials; (5) There are severe heart block and/or severe ventricular dysfunction, such as sick sinus syndrome, II degree II block or more; (6) With serious heart, lung or kidney disease before surgery; (7) The researchers believe that other reasons are not suitable for clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TNF-a;IL-6; | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxygenation index;Lac;(A-a)DO2;AWP;Urine volume;Creatinine value;Blood urea nitrogen value;Cortisol;Acetylcholine;Blood catecholamine;The amount of catecholamines;Postoperative pulmonary complications;Postoperative renal dysfunction;RI;NGAL;PH;PO2;PCO2;BE;HR;SBP;DBP;MAP;CVP;SVV/SVI;CO/CI;SVR/SVRI; | — |
Countries
China
Contacts
Public ContactGu Jianteng
Anesthesiology Department of the First Affiliated Hospital of Army Medical University, PLA
Outcome results
None listed